Article
New hints towards a precision medicine strategy for IDH wild-type glioblastoma.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Dec 2020
White K, Connor K, Clerkin J, Murphy B M, Salvucci M, O'Farrell A C, Rehm M, O'Brien D, Prehn J H M, Niclou S P, Lamfers M L M, Verreault M, Idbaih A, Verhaak R, Golebiewska A, Byrne A T
Abstract excerpt
Glioblastoma represents the most common primary malignancy of the central nervous system in adults and remains a largely incurable disease. The elucidation of disease subtypes based on mutational profiling, gene expression and DNA methylation has so far failed to translate into improved clinical outcomes. However, new knowledge emerging from the subtyping effort in the IDH-wild-type setting may provide directions...
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