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Article

Variations in the unstructured C-terminal tail of interferons contribute to differential receptor binding and biological activity.

Journal of molecular biology - 28 Jul 2006

Slutzki Michal, Jaitin Diego A, Yehezkel Tuval Ben, Schreiber Gideon

Abstract excerpt

Type I interferons (IFNs) elicit antiviral, antiproliferative and immunomodulatory properties in cells. All of them bind to the same receptor proteins, IFNAR1 and IFNAR2, with different affinities. While the 13 known IFNalphas are highly conserved, the C-terminal unstructured tail was found to have large variation in its net charge, from neutral to +4. This led us to speculate that the tail may have a role in...

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Source

Identifiers

PMID: 16815442
DOI: 10.1016/j.jmb.2006.05.069

Genes

IFNAR2
IFNAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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