Article
IFNA2 p.Ala120Thr impairs the inhibitory activity of Interferon-α2 against the hepatitis B virus through altering its binding to the receptor.
Antiviral research - 1 Nov 2017
Chen Chuming, Zhu Xiang, Xu Wenxiong, Yang Fangji, Zhang Genglin, Wu Lina, Zheng Yongyuan, Gao Zhiliang, Xie Chan, Peng Liang
Abstract excerpt
BACKGROUND: Our previous study found that a rare genetic mutation IFNA2p.Ala120Thr affects the structure of IFN-α2 and contributes to increased host susceptibility to CHB. However, the way in which the single amino acid residue mutation affects IFN-α2 activity is unclear. The purpose of this research was to investigate the effects and mechanisms of IFNA2p.Ala120Thr on IFN-α2 activity. METHODS: Plasmid...
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