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Article

Functional diversity of natural human IFNB1 variants in innate immunity.

Science advances - 18 Sept 2026

Schiefer Samira, Jones David, Kwaschik Florence, Hale Benjamin G

Abstract excerpt

Human interferon-β (IFN-β), a type I IFN, is critical for effective innate immunity and is also an approved disease-modifying therapeutic. While genetic variations in several components of the type I IFN system are associated with infectious and immune diseases, consequences of IFNB1 variation remain unexplored. Here, we functionally evaluated 70 naturally occurring rare protein-altering IFNB1 variants detected...

Read the complete abstract on PubMed

Topics

Humans
Immunity, Innate
Interferon-beta
Receptor, Interferon alpha-beta
Genetic Variation
Signal Transduction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 42758835
DOI: 10.1126/sciadv.aeh4755
PMCID: PMC13588187

Genes

IFNB1
IFNAR1
IFNAR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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