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Article

Determination of the human type I interferon receptor binding site on human interferon‐α2 by cross saturation and an NMR‐based model of the complex

26 Sept 2006

Abstract excerpt

Type I interferons (IFNs) are a family of homologous helical cytokines that exhibit pleiotropic effects on a wide variety of cell types, including antiviral activity and antibacterial, antiprozoal, immunomodulatory, and cell growth regulatory functions. Consequently, IFNs are the human proteins most widely used in the treatment of several kinds of cancer, hepatitis C, and multiple sclerosis. All type I IFNs bind...

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PMID: 17001036
DOI: 10.1110/ps.062283006

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