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Discovery of novel putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in AML cells

2020-10-08

Abstract excerpt

CRISPR knockout screens in hundreds of cancer cell lines have revealed a substantial number of context-specific essential genes that, when associated with a biomarker such as lineage or oncogenic mutation, offer candidate tumor-specific vulnerabilities for targeted therapies or novel drug development. Data-driven analysis of knockout fitness screens also yields many other functionally coherent modules that show em...

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Identifiers and source

Literature Corpus work
1ee71439-ef5f-57cf-9fc3-3b74b938529f
DOI
10.1101/2020.10.08.332023
Open publication

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Discovery of novel putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in AML cellsDOI 10.1101/2020.10.08.332023
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