Article

Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution

2024-09-22

Abstract excerpt

Overall adiposity and body fat distribution are heritable traits associated with altered risk of cardiometabolic disease and mortality. Performing rare variant (minor allele frequency<1%) association testing using exome-sequencing data from 402,375 participants in the UK Biobank (UKB) for nine overall and tissue-specific fat distribution traits, we identified 19 genes where putatively damaging rare variation assoc...

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Literature Corpus work: 7f49882d-7847-5565-ab39-2a4e36f655aa
DOI: 10.1101/2024.09.19.24313913

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