Article

Genetic Compensation Restores Embryonic Viability in Fatty Acid Synthase Mutants

2026-01-14

Abstract excerpt

Fatty acid synthase (FASN) is a key rate-limited, dimeric multi-enzyme complex in the de novo lipogenesis pathway. Each FASN monomer contains seven catalytic domains, which coordinate the stepwise conversion of acetyl-CoA into fatty acids. While FASN has been extensively studied in cultured cells, particularly for its oncogenic role, its functions in the germline and early embryonic development remain elusive. A...

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Literature Corpus work: dbd87c4c-cded-53f6-bcdc-cde21d9f47cc
DOI: 10.64898/2026.01.12.699145

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