Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1.

doi:10.1111/j.1469-1809.1995.tb01603.x

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Article

Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1.

Annals of human genetics - 1 Jan 1995

Henske E P, Short M P, Jozwiak S, Bovey C M, Ramlakhan S, Haines J L, Kwiatkowski D J

Abstract excerpt

A novel widely expressed homologue of the VAV oncogene, VAV2 (53% identical residues), has been identified within the critical region for the tuberous sclerosis gene, TSC1, on human chromosome 9q34. By Southern blot analysis, analysis of allele-specific transcription, and direct sequencing of the...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Cell Cycle Proteins
Chromosome Mapping
Chromosomes, Human, Pair 9
DNA Mutational Analysis
DNA, Complementary
Humans
Molecular Sequence Data
Oncogene Proteins
Oncogenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organ Specificity

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-vav

Sequence Alignment

Sequence Homology, Amino Acid

Tuberous Sclerosis

Source

Open in PubMed

Identifiers

PMID: 7762982
DOI: 10.1111/j.1469-1809.1995.tb01603.x

Genes

VAV2
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7762982-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1.PMID 7762982Read ↗

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.Semantic proximity Read ↗

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34.Semantic proximity Read ↗

Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.Semantic proximity Read ↗

Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential.Semantic proximity Read ↗

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A high-resolution linkage map of human 9q34.1.Semantic proximity Read ↗

The haematopoietic specific signal transducer Vav1 is expressed in a subset of human neuroblastomasSemantic proximity Read ↗

cDNA sequence and genomic structure of EV12B, a gene lying within an intron of the neurofibromatosis type 1 gene.Semantic proximity Read ↗

Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors.Semantic proximity Read ↗

Large deletion at the TSC1 locus in a family with tuberous sclerosis complex.Semantic proximity Read ↗

Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.Semantic proximity Read ↗

Human Vav1 expression in hematopoietic and cancer cell lines is regulated by c-Myb and by CpG methylation.Semantic proximity Read ↗

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