Article
Mutation of Vav1 adaptor region reveals a new oncogenic activation.
Oncotarget - 10 Feb 2015
Razanadrakoto Lyra, Cormier Françoise, Laurienté Vanessa, Dondi Elisabetta, Gardano Laura, Katzav Shulamit, Guittat Lionel, Varin-Blank Nadine
Abstract excerpt
Vav family members function as remarkable scaffold proteins that exhibit both GDP/GTP exchange activity for Rho/Rac GTPases and numerous protein-protein interactions via three adaptor Src-homology domains. The exchange activity is under the unique regulation by phosphorylation of tyrosine residues hidden by intra-molecular interactions. Deletion of the autoinhibitory N-terminal region results in an oncogenic...
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