The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.

doi:10.1002/j.1460-2075.1995.tb06969.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.

The EMBO journal - 3 Jan 1995

Zmuidzinas A, Fischer K D, Lira S A, Forrester L, Bryant S, Bernstein A, Barbacid M

Abstract excerpt

Previous studies have suggested that the vav protooncogene plays an important role in hematopoiesis. To study this further, we have ablated the vav protooncogene by homologous recombination in embryonic stem (ES) cells. Homozygous vav (-/-) ES clones differentiate normally in culture and generate cells of erythroid, myeloid and mast cell lineages. Mice heterozygous for the targeted vav allele do not display any...

Topics

Animals
Base Sequence
Cell Cycle Proteins
Cell Differentiation
Cells, Cultured
Embryo Implantation
Female
Gene Expression
Genes, Lethal
Hematopoiesis
Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Homozygote

Mast Cells

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 7828581
DOI: 10.1002/j.1460-2075.1995.tb06969.x
PMCID: PMC398046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7828581-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.PMID 7828581Read ↗

Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential.Semantic proximity Read ↗

Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.Semantic proximity Read ↗

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.Semantic proximity Read ↗

Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice.Semantic proximity Read ↗

c-mycin the hematopoietic lineage is crucial for its angiogenic function in the mouse embryoSemantic proximity Read ↗

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.Semantic proximity Read ↗

The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development.Semantic proximity Read ↗

Evi‐1 promotes para‐aortic splanchnopleural hematopoiesis through up‐regulation of GATA‐2 and repression of TGF‐b signalingSemantic proximity Read ↗

Regulation of the vav proto-oncogene by LKLF.Semantic proximity Read ↗

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survivalSemantic proximity Read ↗

Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice.Semantic proximity Read ↗

The haematopoietic specific signal transducer Vav1 is expressed in a subset of human neuroblastomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.