Article
Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.
The Journal of biological chemistry - 23 Jul 2010
Lazer Galit, Pe'er Liron, Farago Marganit, Machida Kazuya, Mayer Bruce J, Katzav Shulamit
Abstract excerpt
The guanine nucleotide exchange factor (GEF) Vav1 is an essential signal transducer protein in the hematopoietic system, where it is expressed physiologically. It is also involved in several human malignancies. Tyrosine phosphorylation at the Vav1 amino terminus plays a central role in regulating its activity; however, the role of carboxyl terminal tyrosine residues is unknown. We found that mutation of either...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Cattle
- Cell Transformation, Neoplastic
- Enzyme Activation
- Humans
- Jurkat Cells
- Mice
- Molecular Sequence Data
- Mutation
- NFATC Transcription Factors
- Pancreatic Neoplasms