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Article

Vav1 mutations: What makes them oncogenic?

Cellular signalling - 1 Jan 2020

Farago Marganit, Yarnitzky Tali, Shalom Batel, Katzav Shulamit

Abstract excerpt

Vav1 is physiologically active as a GDP/GTP nucleotide exchange factor (GEF) in the hematopoietic system. Its wild-type form was recently implicated in mammalian malignancies of hematologic and non-hematologic tissue origins. Moreover, it was recently identified as a mutated gene in human cancers of various origins. In this review we focus on the functional activities of several of the Vav1 mutants analyzed for...

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Identifiers

PMID: 31654719
DOI: 10.1016/j.cellsig.2019.109438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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