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Article

Unraveling the Oncogenic Potential of VAV1 in Human Cancer: Lessons from Mouse Models.

Cells - 27 Apr 2023

Shalom Batel, Salaymeh Yaser, Risling Matan, Katzav Shulamit

Abstract excerpt

VAV1 is a hematopoietic signal transducer that possesses a GDP/GTP nucleotide exchange factor (GEF) that is tightly regulated by tyrosine phosphorylation, along with adapter protein domains, such as SH2 and SH3. Research on VAV1 has advanced over the years since its discovery as an in vitro activated oncogene in an NIH3T3 screen for oncogenes. Although the oncogenic form of VAV1 first identified in the screen has...

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PMID: 37174676
DOI: 10.3390/cells12091276
PMCID: PMC10177506

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