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Discovery of Diverse CRISPR-Cas Systems and Expansion of the Genome Engineering Toolbox

16 May 2023

Abstract excerpt

CRISPR systems mediate adaptive immunity in bacteria and archaea through diverse effector mechanisms and have been repurposed for versatile applications in therapeutics and diagnostics thanks to their facile reprogramming with RNA guides. RNA-guided CRISPR-Cas targeting and interference are mediated by effectors that are either components of multisubunit complexes in class 1 systems or multidomain single-effector...

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PMID: 37192099
DOI: 10.1021/acs.biochem.3c00159

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