Article

A critical but divergent role of PRDM14 in human primordial germ cell fate revealed by inducible degrons

2019-02-27

Abstract excerpt

PRDM14 is a crucial regulator of mouse primordial germ cells (mPGC), epigenetic reprogramming and pluripotency, but its role in the evolutionarily divergent regulatory network of human PGCs (hPGCs) remains unclear. Besides, a previous knockdown study indicated that PRDM14 might be dispensable for human germ cell fate. Here, we decided to use inducible degrons for a more rapid and comprehensive PRDM14 depletion. We...

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Literature Corpus work: 530788da-02b9-5786-bd34-d960d27b0690
DOI: 10.1101/563072

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