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Article

Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice.

PloS one - 1 Jan 2013

Schemmer Jana, Araúzo-Bravo Marcos J, Haas Natalie, Schäfer Sabine, Weber Susanne N, Becker Astrid, Eckert Dawid, Zimmer Andreas, Nettersheim Daniel, Schorle Hubert

Abstract excerpt

Maintenance and maturation of primordial germ cells is controlled by complex genetic and epigenetic cascades, and disturbances in this network lead to either infertility or malignant aberration. Transcription factor TFAP2C has been described to be essential for primordial germ cell maintenance and to be upregulated in several human germ cell cancers. Using global gene expression profiling, we identified genes...

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Chromatin Immunoprecipitation
Embryonic Stem Cells
Germ Cells
Haploinsufficiency
Kruppel-Like Factor 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription Factor AP-2

Transcriptional Activation

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PMID: 23967156
DOI: 10.1371/journal.pone.0071113
PMCID: PMC3742748

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