Article

Development and Characterization of the Mode-of-Action of Inhibitory and Agonist Peptides Targeting the Voltage-Gated Sodium Channel SCN1B/β1 Subunit

2023-10-20

Abstract excerpt

<h4>ABSTRACT</h4> Treatment of cardiac arrhythmias by targeting ion channels is challenging, with safe and effective therapies remaining an unmet clinical need. Modeling and experimental studies have shown that a voltage-gated sodium channel (VGSC)-rich nanodomain at edge of the gap junction (GJ) called the perinexus could provide new mechanistic insights into normal and abnormal conduction of action potentials i...

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Literature Corpus work: 5303c386-0855-51f5-a661-a977849fcf4d
DOI: 10.1101/2023.10.19.562974

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Development and Characterization of the Mode-of-Action of Inhibitory and Agonist Peptides Targeting the Voltage-Gated Sodium Channel SCN1B/β1 SubunitDOI 10.1101/2023.10.19.562974Read

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