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Article

Signaling from β1‐ and β2‐adrenergic receptors is defined by differential interactions with PDE4

10 Jan 2008

Abstract excerpt

Beta1- and beta2-adrenergic receptors (betaARs) are highly homologous, yet they play clearly distinct roles in cardiac physiology and pathology. Myocyte contraction, for instance, is readily stimulated by beta1AR but not beta2AR signaling, and chronic stimulation of the two receptors has opposing effects on myocyte apoptosis and cell survival. Differences in the assembly of macromolecular signaling complexes may...

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PMID: 18188154
DOI: 10.1038/sj.emboj.7601968

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