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Article

Voltage-gated Na<sup>+</sup>channels: Potential for β subunits as therapeutic targets

12 Aug 2008

Abstract excerpt

BACKGROUND: Voltage gated Na(+) channels (VGSCs) contain a pore-forming alpha subunit and one or more beta subunits. VGSCs are involved in a wide variety of pathophysiologies, including epilepsy, cardiac arrhythmia, multiple sclerosis, periodic paralysis, migraine, neuropathic and inflammatory pain, Huntington's disease and cancer. Increasing evidence implicates the beta subunits as key players in these...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 18694383
DOI: 10.1517/14728222.12.9.1191

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