Article

Heterozygous Loss of Scn1b Results in Concealed Conduction Phenotype Unmasked by Osmotic Stress

2026-06-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> SCN1B encodes the β-subunits of the main cardiac voltage-gated sodium channel, Na V 1.5. Variants are linked to cardiac conduction disease, often with concealed phenotypes. Whether β1-subunits regulate conduction through nanoscale intercalated disc (ID) structures, e.g. perinexi, and ephaptic coupling remains unresolved. <h4>Objective</h4> Test whether Scn1b haploinsuffici...

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Literature Corpus work: 85b5947f-9654-5a94-84c5-81d48bdbcd52
DOI: 10.64898/2026.06.15.732501

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