Article

Patterns of convergent somatic hypermutations in the adaptive immune response of Mus musculus

2022-10-14

Abstract excerpt

We analyzed a dataset of 964 clonally unrelated murine antibodies for which structures have been deposited in the PDB. 454 of the 964 antibodies have gapless germline assignments and do not have excessive numbers of computationally identified somatic hypermutations (SHMs). About 5,500 SHMs were identified, of which approximately 3,500 are in the framework. We then searched for correlated convergent SHMs, i.e. grou...

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Literature Corpus work: 52f99529-385c-53f8-8cd4-f24b0e2fbc8e
DOI: 10.1101/2022.10.12.510618

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