Article
Targets of somatic hypermutation within immunoglobulin light chain genes in zebrafish.
Immunology - 1 Feb 2011
Marianes Alexis E, Zimmerman Anastasia M
Abstract excerpt
In mammals, somatic hypermutation (SHM) of immunoglobulin (Ig) genes is critical for the generation of high-affinity antibodies and effective immune responses. Knowledge of sequence-specific biases in the targeting of somatic mutations can be useful for studies aimed at understanding antibody repertoires produced in response to infections, B-cell neoplasms, or autoimmune disease. To evaluate potential nucleotide...
Topics
- Amino Acid Motifs
- Animals
- Cytidine
- Cytidine Deaminase
- Gene Library
- Genes, Immunoglobulin Light Chain
- Immunoglobulin Light Chains
- Models, Immunological
- Molecular Sequence Data
- Mutation
- Sequence Analysis, DNA