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Article

Targets of somatic hypermutation within immunoglobulin light chain genes in zebrafish.

Immunology - 1 Feb 2011

Marianes Alexis E, Zimmerman Anastasia M

Abstract excerpt

In mammals, somatic hypermutation (SHM) of immunoglobulin (Ig) genes is critical for the generation of high-affinity antibodies and effective immune responses. Knowledge of sequence-specific biases in the targeting of somatic mutations can be useful for studies aimed at understanding antibody repertoires produced in response to infections, B-cell neoplasms, or autoimmune disease. To evaluate potential nucleotide...

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Identifiers

PMID: 21070232
DOI: 10.1111/j.1365-2567.2010.03358.x
PMCID: PMC3050447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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