Comparative analysis of human and mouse immunoglobulin variable heavy regions from IMGT/LIGM-DB with IMGT/HighV-QUEST.

doi:10.1186/1742-4682-11-30

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Article

Comparative analysis of human and mouse immunoglobulin variable heavy regions from IMGT/LIGM-DB with IMGT/HighV-QUEST.

Theoretical biology & medical modelling - 3 Jul 2014

Shi Bin, Ma Long, He Xiaoyan, Wang Xiaomei, Wang Peng, Zhou Li, Yao Xinsheng

Abstract excerpt

BACKGROUND: Immunoglobulin (IG) complementarity determining region (CDR) includes VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3. Of these, VH CDR3 plays a dominant role in recognizing and binding antigens. Three major mechanisms are involved in the formation of the VH repertoire: germli...

Topics

Amino Acid Sequence
Animals
Base Sequence
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Mice
Mutation

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