Article

Within-host adaptive evolution is limited by genetic drift in experimental human influenza A virus infections

2026-01-07

Abstract excerpt

Selection of advantageous mutations drives the emergence of dominant variants during seasonal influenza epidemics. However, within-host detection of such variants remains rare, limiting our understanding of how selection operates at the scale of individual hosts. In this study, we used a controlled human infection model to examine the within-host evolutionary dynamics in thirteen participants intranasally infected...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a254e95-380c-519a-a8c6-dec77dbf4566
DOI: 10.64898/2026.01.07.698006

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Within-host adaptive evolution is limited by genetic drift in experimental human influenza A virus infectionsDOI 10.64898/2026.01.07.698006Read

Stochastic processes dominate the within and between host evolution of influenza virusSemantic proximity Read

Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammalsSemantic proximity Read

Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck.Semantic proximity Read

Stochastic processes constrain the within and between host evolution of influenza virus.Semantic proximity Read

Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young childrenSemantic proximity Read

Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young childrenSemantic proximity Read

Selection on haemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza viruses.Semantic proximity Read

Recent Human Influenza A/H3N2 Virus Evolution Driven by Novel Selection Factors in Addition to Antigenic DriftSemantic proximity Read

Influenza A genomic diversity during human infections underscores the strength of genetic drift and the existence of tight transmission bottlenecksSemantic proximity Read

Evolutionary constraints limit additional mammalian adaptation of bovine-derived H5N1 influenza viruses in ferretsSemantic proximity Read

Within-Host Evolution of Human Influenza Virus.Semantic proximity Read

Adaptive selection of quasispecies during in vivo passaging in chickens, mice, and ferrets results in host-specific strains for the H9N2 avian influenza virus.Semantic proximity Read