Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2015

Winarski Katie L, Thornburg Natalie J, Yu Yingchun, Sapparapu Gopal, Crowe James E, Spiller Benjamin W

Abstract excerpt

Antigenic drift of circulating seasonal influenza viruses necessitates an international vaccine effort to reduce the impact on human health. A critical feature of the seasonal vaccine is that it stimulates an already primed immune system to diversify memory B cells to recognize closely related, but antigenically distinct, influenza glycoproteins (hemagglutinins). Influenza pandemics arise when hemagglutinins to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Viral
Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Fragments

Share to Influenza A Virus, H5N1 Subtype

Share to Influenza, Human

Share to Influenza Vaccines

Share to Molecular Conformation

Share to N-Acetylneuraminic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 26170302
DOI: 10.1073/pnas.1502762112
PMCID: PMC4522792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.PMID 26170302Read ↗

Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding SiteSemantic proximity Read ↗

Identification and Structural Characterization of a Broadly Neutralizing Antibody Targeting a Novel Conserved Epitope on the Influenza Virus H5N1 HemagglutininSemantic proximity Read ↗

Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem.Semantic proximity Read ↗

Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza virusesSemantic proximity Read ↗

Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibodySemantic proximity Read ↗

Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity.Semantic proximity Read ↗

A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus.Semantic proximity Read ↗

A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus HemagglutininSemantic proximity Read ↗

Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodiesSemantic proximity Read ↗

Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodiesSemantic proximity Read ↗

Identification of Hemagglutinin Residues Responsible for H3N2 Antigenic Drift during the 2014-2015 Influenza Season.Semantic proximity Read ↗

Structural basis of broad protection against influenza virus by human antibodies targeting the neuraminidase active site via a recurring motif in CDR H3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.