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Article

Deep Sequencing Reveals Potential Antigenic Variants at Low Frequencies in Influenza A Virus-Infected Humans.

Journal of virology - 6 Jan 2016

Dinis Jorge M, Florek Kelsey R, Fatola Omolayo O, Moncla Louise H, Mutschler James P, Charlier Olivia K, Meece Jennifer K, Belongia Edward A, Friedrich Thomas C

Abstract excerpt

UNLABELLED: Influenza vaccines must be frequently reformulated to account for antigenic changes in the viral envelope protein, hemagglutinin (HA). The rapid evolution of influenza virus under immune pressure is likely enhanced by the virus's genetic diversity within a host, although antigenic change has rarely been investigated on the level of individual infected humans. We used deep sequencing to characterize...

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Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Influenza A Virus, H1N1 Subtype

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Source

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Identifiers

PMID: 26739054
DOI: 10.1128/JVI.03248-15
PMCID: PMC4794676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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