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Article

Tissue-specific N terminus of the HCN4 channel affects channel activation.

The Journal of biological chemistry - 22 Apr 2011

Liu He, Aldrich Richard W

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed in the brain and heart and are essential for physiological functions in cardiac and nervous systems. We identified two Hcn4 mRNA variants with different transcription start sites and differential expression patterns in mouse brain and heart. Only one mRNA variant was detected in the brain, whereas both variants were found in the...

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Source

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Identifiers

PMID: 21372143
DOI: 10.1074/jbc.M110.215640
PMCID: PMC3077622

Genes

HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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