Article
Molecular diversity of pacemaker ion channels.
Annual review of physiology - 1 Jan 2001
Kaupp U B, Seifert R
Abstract excerpt
Ionic currents activated by hyperpolarization and regulated by cyclic nucleotides were first discovered more than 20 years ago. Recently the molecular identity of the underlying channels has been unveiled. The structural features of the protein sequences are discussed and related to the mechanisms of activation, selectivity for cyclic nucleotides, and ion permeation. Coverage includes a comparison of the...
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