Molecular diversity of pacemaker ion channels.

doi:10.1146/annurev.physiol.63.1.235

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Article

Molecular diversity of pacemaker ion channels.

Annual review of physiology - 1 Jan 2001

Kaupp U B, Seifert R

Abstract excerpt

Ionic currents activated by hyperpolarization and regulated by cyclic nucleotides were first discovered more than 20 years ago. Recently the molecular identity of the underlying channels has been unveiled. The structural features of the protein sequences are discussed and related to the mechanisms of activation, selectivity for cyclic nucleotides, and ion permeation. Coverage includes a comparison of the...

Topics

Animals
Biological Clocks
Cyclic Nucleotide-Gated Cation Channels
Genetic Variation
Humans
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Ion Channels
Molecular Sequence Data
Muscle Proteins
Nerve Tissue Proteins
Potassium Channels
Sequence Homology, Amino Acid
Sinoatrial Node

Source

Open in PubMed

Identifiers

PMID: 11181956
DOI: 10.1146/annurev.physiol.63.1.235

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