Article

Structure of the integrin receptor α <sub>M</sub> β <sub>2</sub> headpiece in complex with a function-modulating nanobody

2021-07-08

Abstract excerpt

The integrin receptor α M β 2 mediates phagocytosis of complement-opsonized objects, adhesion to the extracellular matrix and trans-endothelial migration of leukocytes. Here we present the first atomic structure of the human α M β 2 headpiece fragment in complex with the nanobody hCD11bNb1 determined at a resolution of 3.2 Å. The receptor headpiece adopts the closed conformation expected to have low ligand aff...

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Literature Corpus work: 526b6845-7756-50c7-a972-a63fad5c37be
DOI: 10.1101/2021.07.07.451531

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Structure of the integrin receptor α <sub>M</sub> β <sub>2</sub> headpiece in complex with a function-modulating nanobodyDOI 10.1101/2021.07.07.451531Read

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