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Article

An anti-HER2 nanobody binds to its antigen HER2 via two independent paratopes.

International journal of biological macromolecules - 1 Jul 2021

Ubbiali Daniele, Orlando Marco, Kovačič Matic, Iacobucci Claudio, Semrau Marta S, Bajc Gregor, Fortuna Sara, Ilc Gregor, Medagli Barbara, Oloketuyi Sandra, Storici Paola, Sinz Andrea, Grandori Rita, de Marco Ario

Abstract excerpt

High-resolution structural data of complexes between antibodies and membrane receptors still represent a demanding task. In this study, we used complementary sets of experimental data to obtain a structural model of the complex formed by the human epidermal growth factor receptor 2 (HER2) and its specific nanobody A10. First we identified by NMR the residues that bind or rearrange as a consequence of the complex...

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Share to Binding Sites, Antibody
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 33848543
DOI: 10.1016/j.ijbiomac.2021.04.032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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