Article

Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies

2023-02-22

Abstract excerpt

The human complement system plays a crucial role in immune defense. However, its erroneous activation contributes to many serious inflammatory diseases. Since most unwanted complement effector functions result from C5 cleavage, development of C5 inhibitors, such as clinically approved monoclonal antibody Eculizumab, are of great interest. In this study, we developed and characterized two anti-C5 nanobodies, UNbC5-...

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Literature Corpus work: 3675e4b5-9859-5f45-a11a-4b6177cfd6b5
DOI: 10.1101/2023.02.22.529391

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