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Multifaceted Activities of Seven Nanobodies against Complement C4b

15 Apr 2022

Abstract excerpt

Abstract Cleavage of the mammalian plasma protein C4 into C4b initiates opsonization, lysis, and clearance of microbes and damaged host cells by the classical and lectin pathways of the complement system. Dysregulated activation of C4 and other initial components of the classical pathway may cause or aggravate pathologies, such as systemic lupus erythematosus, Alzheimer disease, and schizophrenia. Modulating the...

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PMID: 35428691
DOI: 10.4049/jimmunol.2100647

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