Article

Monitoring ligand-induced changes in receptor conformation with NanoBiT conjugated nanobodies

2020-04-23

Abstract excerpt

<h4>Summary</h4> Camelid single-domain antibody fragments (nanobodies) offer the specificity of an antibody in a single 15kDa immunoglobulin domain. Their small size allows for easy genetic manipulation of the nanobody sequence to incorporate protein tags, facilitating their use as biochemical probes. The nanobody VUN400, which recognises the second extracellular loop of the human CXCR4 chemokine receptor, was us...

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Literature Corpus work: 90b485cb-1d95-5744-8d37-f4d097713a75
DOI: 10.1101/2020.04.21.032086

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