Article
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Luo Bing-Hao, Springer Timothy A, Takagi Junichi
Abstract excerpt
The affinity of the extracellular domain of integrins for ligand is regulated by conformational changes signaled from the cytoplasm. Alternative types of conformational movement in the ligand-binding headpiece have been proposed. In one study, electron micrograph image averages of the headpiece of integrin aV beta 3 show two different conformations. The open conformation of the headpiece is present when a ligand...
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