Article

Heavy chain-1 of inter-α-inhibitor has an integrin-like structure with immune regulatory activities

2019-07-08

Abstract excerpt

Inter-α-inhibitor (IαI) is a proteoglycan essential for mammalian reproduction that also plays a less well-characterised role in inflammation. IαI is composed of 2 homologous ‘heavy chains’ (HC1 and HC2) covalently attached to chondroitin sulphate on the bikunin core protein. Prior to ovulation HCs are transferred onto the polysaccharide hyaluronan (HA), thereby stabilising a matrix that is required for fertilisat...

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Literature Corpus work: b61d4cee-e554-526a-8fa5-84731cbd7b39
DOI: 10.1101/695700

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