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Article

Dual function for a unique site within the beta2I domain of integrin alphaMbeta2.

The Journal of biological chemistry - 4 Mar 2005

Ehirchiou Driss, Xiong Yu-Mei, Li Yang, Brew Shelesa, Zhang Li

Abstract excerpt

Integrin activation has been postulated to occur in part via conformational changes in the I domain of the beta subunit (the betaI domain), especially near the F-alpha(7) loop, in response to "inside-out" signaling. However, direct evidence for a role of the F-alpha(7) loop in ligand binding and activity modulation is still lacking. Here, we report our finding that the F-alpha(7) loop (residues 344-358) within...

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Source

Identifiers

PMID: 15615722
DOI: 10.1074/jbc.M413525200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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