Article

Transcriptomic convergence despite genomic divergence drive field cancerization in synchronous squamous tumors

2021-03-09

Abstract excerpt

<title>Abstract</title> <p>Field cancerization is suggested to arise from imbalanced differentiation in individual basal progenitor cells leading to clonal expansion of mutant cells that eventually replace the epithelium, although without evidence. Through deep sequencing analyses, we characterized the genomic and transcriptomic landscapes of field change in two patients with synchronous aerodigestive tract tumor...

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Literature Corpus work: 526a6c74-b638-5448-b51a-e12d608b2b43
DOI: 10.21203/rs.3.rs-308860/v1

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