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Article

An evolutionary perspective on field cancerization.

Nature reviews. Cancer - 1 Jan 2018

Curtius Kit, Wright Nicholas A, Graham Trevor A

Abstract excerpt

Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed, even before any of the usual morphological correlates of pre-malignancy are recognizable. Field cancerization, which is the replacement of the normal cell population by a cancer-primed cell population that may show no morphological change, is now recognized to underlie the development of many types of cancer, including the...

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Identifiers

PMID: 29217838
DOI: 10.1038/nrc.2017.102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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