Article
Field cancerization in the GI tract.
Future oncology (London, England) - 1 Aug 2011
Graham Trevor A, McDonald Stuart Ac, Wright Nicholas A
Abstract excerpt
The widely accepted paradigm for tumorigenesis begins with rate-limiting mutations in a key growth control gene resulting in immediate lesion growth. Tumor progression occurs as cells within the tumor acquire additional carcinogenic mutations. However, there is clear evidence that the road to cancer can begin long before the growth of a clinically detectable lesion - indeed, long before any of the usual...
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