Article

Pan-cancer organoid validation of tumor outlier chromosomal amplification events

2021-10-06

Abstract excerpt

<h4>SUMMARY</h4> Somatic copy number gains are pervasive in many cancer types, yet their roles in oncogenesis are often poorly explored. This lack of understanding is in part due to broad extensions of copy gains across cancer genomes spanning large chromosomal regions, obscuring causal driver loci. Here we employed a multi-tissue pan-organoid modeling approach to validate candidate oncogenic loci identified with...

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Literature Corpus work: ad103459-50dc-5ac6-af14-21b9d4400c40
DOI: 10.1101/2021.10.05.463147

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