Article

Mutational analysis of field cancerization in bladder cancer

2019-01-31

Abstract excerpt

The multifocal and recurrent nature of bladder cancer has been explained by field cancerization of the bladder urothelium. To shed light on field cancerization in the bladder, we investigated the mutational landscape of normal appearing urothelium and paired bladder tumors from four patients. Sequencing of 509 cancer driver genes revealed the presence of 2-16 mutations exclusively localized in normal tissue (avera...

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Literature Corpus work: 131bfe78-3469-5916-aee9-519559da81f2
DOI: 10.1101/536466

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