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Mutational Context and Diverse Clonal Development in Early and Late Bladder Cancer

15 May 2014

Abstract excerpt

Bladder cancer (or urothelial cell carcinoma [UCC]) is characterized by field disease (malignant alterations in surrounding mucosa) and frequent recurrences. Whole-genome, exome, and transcriptome sequencing of 38 tumors, including four metachronous tumor pairs and 20 superficial tumors, identified an APOBEC mutational signature in one-third. This was biased toward the sense strand, correlated with mean...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 24835989
DOI: 10.1016/j.celrep.2014.04.038

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