Article
Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay.
SLAS discovery : advancing life sciences R & D - 1 Jan 2019
Spicer Timothy P, Gardiner Donald L, Schoenen Frank J, Roy Sudeshna, Griffin Patrick R, Chase Peter, Scampavia Louis, Hodder Peter, Trenholme Katharine R
Abstract excerpt
Malaria remains a major cause of morbidity and mortality worldwide with ~3.3 billion people at risk of contracting malaria and an estimated 450,000 deaths each year. While tools to reduce the infection prevalence to low levels are currently under development, additional efforts will be required to interrupt transmission. Transmission between human host and vector by the malaria parasite involves gametogenesis in...
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