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Article

Phenotypic profiling of Pathogen Box compounds MMV667494 and MMV028694 in bloodstream-form Trypanosoma brucei brucei.

Experimental biology and medicine (Maywood, N.J.) - 1 Jan 2026

Akazue Pearl Ihuoma, Quashie Neils Ben, Vaughan Sue, de Koning Harry P, Gwira Theresa Manful

Abstract excerpt

Open-access drug discovery platforms have accelerated hit identification and lead prioritization across multiple diseases and enable systematic repurposing of bioactive compounds beyond their original indications. However, there remains a need for new chemotypes for African trypanosomiasis with improved efficacy and resilience to emerging drug resistance. In this study, we evaluated the antitrypanosomal potential...

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Identifiers

PMID: 42367322
DOI: 10.3389/ebm.2026.10979
PMCID: PMC13303395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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