Back to search

Article

Inhibition of protein N-myristoylation blocks <i>Plasmodium falciparum</i> intraerythrocytic development, egress, and invasion

2020-12-16

Abstract excerpt

<h4>ABSTRACT</h4> We have combined chemical biology and genetic modification approaches to investigate the importance of protein myristoylation in the human malaria parasite, Plasmodium falciparum . Parasite treatment during schizogony in the last ten to fifteen hours of the erythrocytic cycle with IMP-1002, an inhibitor of N -myristoyl transferase (NMT), led to a significant blockade in parasite egress from th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c773130d-1837-518d-9d17-005ba7d2cab5
DOI
10.1101/2020.12.16.423054
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Inhibition of protein N-myristoylation blocks <i>Plasmodium falciparum</i> intraerythrocytic development, egress, and invasionDOI 10.1101/2020.12.16.423054
MMV687794 blocks <i>Plasmodium falciparum</i> invasion of red blood cells by targeting a Surface-associated Lipid-Interacting Rhoptry Protein, <i>Pf</i> SLIRPSemantic proximity
Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.Semantic proximity
Identification of potent and selective <i>N</i> -myristoyltransferase inhibitors of <i>Plasmodium vivax</i> liver stage hypnozoites and schizontsSemantic proximity
Palmitoyl transferases have critical roles in the development of mosquito and liver stages ofPlasmodiumSemantic proximity
Characterisation of Two <i>Plasmodium</i> Virulence Factors Important for Lipid Metabolism and Disease Progression <i>In Vivo</i>Semantic proximity
Pivotal roles of <i>Plasmodium falciparum</i> lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalizationSemantic proximity
Whole Cell Phenotypic Screening Of MMV Pathogen Box identifies Specific Inhibitors of <i>Plasmodium falciparum</i> merozoite maturation and egressSemantic proximity
Plasmodium falciparum rhoptry proteins play diverse roles in the asexual erythrocytic life cycle, including in erythrocyte invasion, protein export and nutrient importSemantic proximity
<i>Plasmodium</i> RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasionSemantic proximity
Multi-omics dissection of stage-specific artemisinin tolerance mechanisms in Kelch13-mutant Plasmodium falciparum.Semantic proximity
<i>Babesia divergens</i> egress from host cells is orchestrated by essential and druggable kinases and proteasesSemantic proximity
Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite developmentSemantic proximity
Select a neighboring publication to make it the new centre.