Article

Early degeneration of motor pathways in prodromal Parkinson’s disease: A fixel-based structural connectivity analysis

2026-01-08

Abstract excerpt

<h4>Background</h4> Idiopathic REM sleep behavior disorder (iRBD) and hyposmia are the strongest clinical indicators of prodromal Parkinson’s disease, reflecting distinct proposed pathways of α-synuclein pathology propagation. According to the body-first/brain-first model, iRBD represents a body-first phenotype with early brainstem involvement, whereas hyposmia may reflect a brain-first phenotype with early limbi...

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Literature Corpus work: 526496c2-b9ef-5ca6-be7c-51d93a64fbc6
DOI: 10.64898/2026.01.07.26343523

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