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Article

Fiber-Specific White Matter Alterations in Parkinson's Disease Patients with GBA Gene Mutations.

Movement disorders : official journal of the Movement Disorder Society - 1 Nov 2023

Andica Christina, Kamagata Koji, Uchida Wataru, Saito Yuya, Takabayashi Kaito, Hagiwara Akifumi, Takeshige-Amano Haruka, Hatano Taku, Hattori Nobutaka, Aoki Shigeki

Abstract excerpt

BACKGROUND: Patients with Parkinson's disease (PD) carrying GBA gene mutations (GBA-PD) have a more aggressive disease course than those with idiopathic PD (iPD). OBJECTIVE: The objective of this study was to investigate fiber-specific white matter (WM) differences in nonmedicated patients with early-stage GBA-PD and iPD using fixel-based analysis, a novel technique to assess tract-specific WM microstructural and...

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Identifiers

PMID: 37608502
DOI: 10.1002/mds.29578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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