Article

Mitochondrial dysfunction underlies cortical atrophy in prodromal synucleinopathies

2022-09-02

Abstract excerpt

<h4>ABSTRACT</h4> Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal synucleinopathy characterized by several changes including brain atrophy. The mechanisms underlying atrophy in iRBD are poorly understood. Here, we performed imaging transcriptomics and comprehensive spatial mapping in a multicentric cohort of 171 polysomnography-confirmed iRBD patients and 238 controls with T1-weighted MRI...

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Literature Corpus work: 48f12092-909d-5a96-8349-0c8a7aef7d1f
DOI: 10.1101/2022.09.01.22279508

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