Article
Clinical progression and genetic pathways in body-first and brain-first Parkinson's disease.
Molecular neurodegeneration - 20 Jun 2025
Passaretti Massimiliano, Veréb Daniel, Mijalkov Mite, Chang Yu-Wei, Zhao Hang, Zufiria-Gerbolés Blanca, Sun Jiawei, Volpe Giovanni, Rivera Natalia, Bologna Matteo, Pereira Joana B
Abstract excerpt
BACKGROUND: Parkinson’s disease (PD) is a highly heterogeneous disorder with distinct phenotypes that can develop well before motor symptoms appear. Recently, two main phenotypes based on the different pathological spreading patterns of PD have been proposed: “body-first”, where α-synuclein pathology begins in the peripheral nervous system and spreads symmetrically from bottom-up, and “brain-first”, where...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.